Author

J. Funk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:proteomics· 2 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

P. Bieling· 3 shared S. Raunser· 3 shared F. Merino· 2 shared A. Belyy· 1 shared A. Biran· 1 shared A. Borowek· 1 shared A. C. Joerger· 1 shared A. Groth· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersBiochemistry

P. Bieling

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Acute multi-level response to defective de novo chromatin assembly in S-phase

J. Dreyer, G. Ricci, J. van den Berg, V. Bhardwaj, J. Funk, C. Armstrong, V. van Batenburg, C. Sine, M. A. Vaninsberghe, R. Marsman, I. K. Mandemaker, S. di Sanzo, J. Costantini, S. Manzo, A. Biran, , F. Mattiroli

This study investigates the acute effects of CAF-1 loss on chromatin assembly during S-phase, revealing multi-level responses including replication slowdown and histone modification changes.

bioRxiv · Mar 22, 2024Cell Biology

Functional diversity of the TP53 mutome revealed by saturating CRISPR mutagenesis

J. Funk, M. Klimovich, E. Pavlakis, M. Neumann, D. Drangenstein, M. Noeparast, P. Hunold, A. Borowek, D.-I. Balourdas, K. Kochan, N. Merle, I. Bullwinkel, M. Wanzel, S. Elmshauser, A. Nist, , T. Stiewe

This study uses CRISPR mutagenesis to analyze the functional impact of TP53 mutations across 9,225 variants, revealing their effects on tumor cell fitness and metastasis.

bioRxiv · Mar 10, 2023Cancer Biology

Mechanism of threonine ADP-ribosylation of F-actin by a Tc toxin

A. Belyy, F. Lindemann, D. Roderer, J. Funk, B. Bardiaux, J. Protze, P. Bieling, H. Oschkinat, S. Raunser

This study reveals how TccC3 toxin modifies F-actin by ADP-ribosylating threonine-148, disrupting actin dynamics and causing cell death.

bioRxiv · May 6, 2022Biochemistry

A structure-derived mechanism reveals how capping protein promotes nucleation in branched actin networks

J. Funk, F. Merino, M. Schaks, K. Rottner, S. Raunser, P. Bieling

This study reveals how capping protein (CP) promotes nucleation in branched actin networks by controlling access to terminal actin subunits and inhibiting nucleation promoting factors.

bioRxiv · Mar 15, 2021Biochemistry

Profilin and formin constitute a pacemaker system for robust actin filament growth

J. Funk, F. Merino, L. Venkova, P. Vargas, S. Raunser, M. Piel, P. Bieling

This study shows that profilin and formin work together to control actin filament growth rates, making them resilient to changes in soluble actin concentrations.

bioRxiv · Aug 15, 2019Biochemistry