M. Neumann

Gut microbiome-based prediction of autoimmune neuroinflammation

The paper identifies a microbial risk factor for autoimmune neuroinflammation by analyzing microbiota compositions and host immune responses in a mouse model of multiple sclerosis.

Functional diversity of the TP53 mutome revealed by saturating CRISPR mutagenesis

This study uses CRISPR mutagenesis to analyze the functional impact of TP53 mutations across 9,225 variants, revealing their effects on tumor cell fitness and metastasis.

The gene expression classifier ALLCatchR identifies B-precursor ALL subtypes and underlying developmental trajectories across age

ALLCatchR, a machine learning classifier, accurately assigns B-precursor ALL samples to molecular subtypes and identifies developmental trajectories using RNA-Seq data.

Drought selection on Arabidopsis populations and their microbiomes

This study identifies geography-dependent microbiome differences in Arabidopsis thaliana populations and links them to drought-associated host genetics.

Long-term forest monitoring unravels constant mortality rise in European forests

The paper analyzes long-term forest mortality trends in Europe, finding a significant increase in tree mortality rates linked to decreasing soil moisture and drought conditions over the past 25 years.

A 3D gene expression atlas of the floral meristem based on spatial reconstruction of single nucleus RNA sequencing data

The paper reconstructs 3D gene expression patterns in a floral meristem using single-nuclei RNA-seq and spatial reconstruction to study cell identity and organ patterning.

Deprivation of dietary fiber in specific-pathogen-free mice promotes susceptibility to the intestinal mucosal pathogen Citrobacter rodentium

This study shows that a low-fiber diet in SPF mice increases susceptibility to Citrobacter rodentium by altering gut microbiota and reducing mucosal barrier integrity.

Sirtuin-1 Sensitive Lysine-136 Acetylation Drives Phase Separation and Pathological Aggregation of TDP-43

This study identifies K136 acetylation as a key modifier of TDP-43's RNA binding and phase separation, leading to pathological aggregation, and shows SIRT1's role in deacetylating and reducing this aggregation.

The relationship between microbial population size and disease in the Arabidopsis thaliana phyllosphere

The paper assesses microbial load and composition in Arabidopsis thaliana phyllosphere using shotgun metagenomics, finding high microbial loads correlate with pathogen proliferation and reduced diversity.

Effects of FLOWERING LOCUS T on FD during the transition to flowering at the shoot apical meristem of Arabidopsis thaliana

This study identifies FD's genome-wide transcriptional targets and shows its role beyond flowering regulation in Arabidopsis thaliana.

Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia

This study identifies subtype and relapse-specific long non-coding RNAs in B cell precursor acute lymphoblastic leukemia and links them to molecular pathways and epigenetic regulation.

Stability of association between Arabidopsis thaliana and Pseudomonas pathogens over evolutionary time scales

The paper surveys Pseudomonas in Arabidopsis thaliana over multiple years and sites, finding that pathogenic sublineages coexist without a single dominant strain overtaking populations.