P. Kaldis

Is the hydrogen of the 2'-hydroxyl group of HENMT1 a Schrodinger's hydrogen?

The paper investigates the catalytic mechanism of HENMT1, revealing that Mg2+ is not essential for substrate binding but is crucial for catalysis, with the 2'-hydroxyl group undergoing deprotonation during methyl transfer.

Catalytic mechanism of the mitochondrial methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2)

This study elucidates the catalytic mechanism of MTHFD2 using computational methods, revealing key residues and magnesium ions involved in its dehydrogenase and cyclohydrolase activities.

Protective functions of ZO-2/Tjp2 expressed in hepatocytes and cholangiocytes against liver injury and cholestasis

This study shows that loss of Tjp2 in hepatocytes and cholangiocytes leads to cholestatic liver disease and increased susceptibility to liver injury, with protective roles in regulating bile acid transporters and detoxification enzymes.