S. Xu

Rete Ridge Topography as a Determinant of Epidermal Stem Cell Identity: Implications for Skin Aging

This study shows that the concave topography of rete ridges influences epidermal stem cell differentiation and function, with changes in topography contributing to skin aging.

Single-Cell and Spatial Transcriptomic Analyses Deciphering the Three-Layer Architecture of Human Tuberculosis Granulomas

This study uses single-cell and spatial transcriptomics to analyze human tuberculosis granulomas, revealing a three-layer structure and identifying potential therapeutic targets.

THE MOLECULAR MECHANISMS OF DEFENSIVE-GRADE ORGANIC ACID BIOSYNTHESIS IN GROUND BEETLES

This study characterizes the defensive chemistry and transcriptomes of two ground beetle species, showing that co-option of primary metabolic pathways contributes to the biosynthesis of formic and methacrylic acids.

Blocking HXA3-mediated neutrophil elastase release during S. pneumoniae lung infection limits pulmonary epithelial barrier disruption and bacteremia

This study identifies HXA3 as a driver of neutrophil transmigration and elastase release during pneumococcal infection, showing that blocking these processes reduces epithelial damage and bacteremia.

AlphaFold2-Guided Functional Screens Reveal a Conserved Antioxidant Protein at ER Membranes

The paper identifies ERGU-1 as a conserved antioxidant protein at ER membranes using AlphaFold2 and functional screens in C. elegans, showing its role in H2O2 detoxification and antioxidant defense.

Differential prevalence and risk factors for infection with coronaviruses in bats collected during 2020 in Yunnan Province, China

The paper examines CoV prevalence in bats from Yunnan Province, identifying new SARSr-CoVs and factors influencing their distribution and zoonotic risk.

Structural insights into transcription regulation of the global virulence factor PhoP from Mycobacterium tuberculosis

This study determines cryo-EM structures of PhoP-dependent transcription complexes in Mtb to elucidate its dual role as activator and repressor in stress adaptation.

Unraveling the Interplay between Stability and Flexibility in Design of Polyethylene Terephthalate (PET) Hydrolases

This study investigates how stability and flexibility balance in PET hydrolases affects catalytic activity, finding that a thermophilic variant shows enhanced performance through structural flexibility.

Improvement in Outcomes and Prevention of Multiple Organ Dysfunction Syndrome After Cardiac Arrest and Successful Cardiopulmonary Resuscitation by Systemic Administration of Bumetanide in Male Mice

This study shows that systemic bumetanide administration after cardiac arrest and CPR improves survival, reduces brain injury, and prevents multiple organ dysfunction in male mice, with LCN2/NGAL identified as a potential biomarker for early neuroprognostication.

Investigation of the mechanism of accelerated biodegradation of Paracoccus-KDSPL-02

This study identifies PROKKA_01468 as a photoreceptor protein in Paracoccus-KDSPL-02 that enhances penicillin G degradation under light.

The role of evolving niche choice in herbivore adaptation to host plants

This study uses an individual-based model to show that niche choice slows insecticide resistance evolution and promotes phenotypic coexistence in phytophagous insects.

A novel VCP modulator, KUS121, attenuates atherosclerosis progression by maintaining intracellular ATP and mitigating ER stress in endothelial cells

This study shows that KUS121 reduces atherosclerosis by maintaining ATP levels and reducing ER stress in endothelial cells.

ZNF574 is a Quality Control Factor For Defective Ribosome Biogenesis Intermediates

The paper identifies ZNF574 as a key factor in a quality control pathway that degrades defective ribosome intermediates in human cells.

Herbivory can increase plant fitness via reduced interspecific competition. Evidence from models and mesocosms

This study shows herbivory can increase plant fitness by reducing interspecific competition, supported by models and mesocosm experiments.

Temporally controlled nervous system-to-gut signaling bidirectionally regulates longevity in Caenorhabditis elegans

This study identifies two neuroendocrine circuits in C. elegans where nervous system signaling to the gut bidirectionally regulates lifespan depending on life stage.

PGC-1a drives small cell neuroendocrine cancer progression towards an ASCL1-expressing subtype with increased mitochondrial capacity

Chemical inhibition of the integrated stress response impairs the ubiquitin-proteasome system

The paper shows that ISRIB impairs UPS degradation in the cytosol during proteotoxic stress, particularly affecting RQC and leading to UPS dysfunction.

The Rhizobial effector NopT targets Nod factor receptors to regulate symbiosis in Lotus japonicus

The paper shows that the rhizobial effector NopT interacts with Nod factor receptors NFR1 and NFR5 in Lotus japonicus to regulate symbiosis by cleaving NFR5 and being counteracted by NFR1 phosphorylation.

Post-death Vesicles of Senescent Bone Marrow Mesenchymal Stromal Polyploids Promote Macrophage Aging and Breast Cancer

Study of Impacts of Two Types of Cellular Aging on the Yeast Bud Morphogenesis

This study analyzes two aging modes in yeast, showing spherical budding cells better control growth and size, and develops a model to test mechanisms of bud morphogenesis during aging.

Impact of alternative splicing on Arabidopsis proteome

This study provides large-scale proteomic evidence that alternative splicing isoforms are translated in plants, showing their impact on protein abundance and plant growth.

Imaging and quantification of prostate cancer-associated bone by polarization-sensitive optical coherence tomography

This study uses PS-OCT to differentiate bone tissue types in prostate cancer metastases by analyzing collagen organization and quantifying structural features.

The Generalized Haldane (GH) model tracking population size changes and resolving paradoxes of genetic drift

The paper integrates the Wright-Fisher and Haldane models to resolve paradoxes in genetic drift by defining it through variance in transmission success rather than population size.

Discovery of Alkenyl Oxindole as a Novel PROTAC Moiety for Targeted Protein Degradation via CRL4DCAF11 Recruitment

The paper develops JQ1-alkenyl oxindole conjugates that degrade BRD4 via the ubiquitin-proteasome system and recruits CRL4DCAF11, identifying HL435 as a potent antitumor lead.

HCCDB v2.0: Decompose the Expression Variations by Single-cell RNA-seq and Spatial Transcriptomics in HCC

HCCDB v2.0 integrates bulk, single-cell, and spatial transcriptomic data from HCC samples to enhance meta-analysis and provide new metrics for gene expression patterns.

TaNF-Y-PRC2 orchestrates temporal control of starch and protein synthesis in wheat

This study identifies the TaNF-Y-PRC2 complex as a regulator of starch and protein synthesis in wheat endosperm, revealing its role in epigenetic control through histone modification and gene repression.

Single-cell transcriptomics reveals cellular hierarchies and aberrant CTS contraction-mediated premature hair regression in androgenetic alopecia

This study uses single-cell transcriptomics to identify cellular hierarchies and CTS contraction as a driver of premature hair regression in AGA, showing ML-7 can improve hair growth.

Distinct roles of H3K27me3 and H3K36me3 in vernalization response, maintenance and resetting in winter wheat

This study identifies distinct roles of H3K27me3 and H3K36me3 in vernalization response, maintenance, and resetting in winter wheat by analyzing transcriptome and chromatin dynamics.

ERLIN1 may be involved in DHRS1-induced Change in Lipid Droplet Morphology in HeLa Cell

This study shows DHRS1 localizes to lipid droplets in HeLa cells and alters their morphology, with ERLIN1 potentially regulating DHRS1's effect on lipid droplet size and triacylglycerol levels.

Lithocholic acid phenocopies rejuvenating and life-extending effects of calorie restriction

This study identifies lithocholic acid as a metabolite that mimics calorie restriction's anti-aging effects in multiple species through AMPK activation.