Elucidating the activation mechanism for GBP1 oligomerization
O. Daumke, M. Weismehl, X. Chu, M. Kutsch, P. Lauterjung, C. Herrmann, M. Kudryashev
This study reveals the activation mechanism of GBP1 oligomerization through cryo-EM structures, showing nucleotide-dependent conformational changes drive dimerization, oligomerization, and membrane binding for pathogen encapsulation.
bioRxiv · Aug 1, 2023 · PreprintBiochemistry