Mechanisms involved in the active secretion of CTX-M-15 β-lactamase by pathogenic E. coli ST131
S. Rangama, I. D. E. A. Lidbury, J. M. Holden…·E. M. H. Wellington
This study identifies CTX-M-15 β-lactamase as an actively secreted enzyme by E. coli ST131 that provides a protective effect against cefotaxime, with secretion mediated through a Type I secretion system rather than outer membrane vesicles.