C. Tang

Chlamydia-driven ISG15 expression dampens the immune response of epithelial cells independently of ISGylation

This study shows that ISG15 expression in epithelial cells infected with Chlamydia trachomatis reduces inflammation and bacterial load without requiring ISGylation.

Enhanced dynamic covalent chemistry for the controlled release of small molecules and biologics from a nanofibrous peptide hydrogel platform

This study develops SABER hydrogels that extend drug release and therapeutic effect for small molecules and biologics in preclinical models.

Advancing knowledge of West African morning glories: a taxonomic revision of Ipomoea L. (Convolvulaceae) from Ghana

This study revises the taxonomy of Ipomoea species in Ghana, identifying 28 species, including five new records, and provides identification tools and conservation notes.

Deciphering the molecular mechanism underlying morphology transition in two-component DNA-protein cophase separation

The paper investigates DNA-protein co-condensates, identifying two morphology transitions and growth dynamics governed by DNA-p53 interaction strength.

PbrSYP71 regulates pollen tube growth by maintaining uneven distribution of the ER in Pyrus

This study identifies PbrSYP71 as a pollen tube-specific syntaxin that maintains uneven ER distribution by tethering ER to F-actin, promoting pollen tube growth in pear.

Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction

This study shows capsaicin directly binds KEAP1 and allosterically activates NRF2, reducing ethanol-induced gastric oxidative damage and suggesting its potential as a novel NRF2 agonist for oxidative stress-related diseases.

Role of Dusp5 KO on Vascular Properties of Middle Cerebral Artery in Rats

This study examines the structural and mechanical properties of the middle cerebral artery in Dusp5 KO rats, finding limited structural changes but enhanced myogenic tone, suggesting Dusp5's role in hemodynamics and cognition is enzyme-driven.

The SLC1A1/EAAT3 Dicarboxylic Amino Acid Transporter is an Epigenetically Dysregulated Nutrient Carrier that Sustains Oncogenic Metabolic Programs

This study identifies SLC1A1/EAAT3 as an oncogenic transporter in ccRCC driven by H3K27ac, showing its role in sustaining metabolic programs and its potential as a therapeutic target.

Enhancement of Protein Stability by Quenching Millisecond Conformational Dynamics

This study links millisecond conformational dynamics of ubiquitin to protein stability through alanine mutations affecting the C-terminal retracted state.

Ubiquitin phosphorylation accelerates protein aggregation and promotes neurodegeneration in the aging brain

This study shows that phosphorylated ubiquitin (pUb) increases with age and contributes to neurodegeneration by impairing proteasomal function and accelerating protein aggregation.

Evaluation of ready-to-use freezer stocks of a synthetic microbial community for maize root colonization

This study evaluates frozen SynCom stocks for maize root colonization, finding they are as effective as fresh SynComs in reproducibility and colonization ability.

cGAS-activating lupus autoantibody for cancer immunotherapy

This study shows a lupus anti-DNA autoantibody activates cGAS and improves survival in glioblastoma models by enhancing CD8+ T cell infiltration.

A Deep Learning Approach for Histology-Based Nuclei Segmentation and Tumor Microenvironment Characterization

This study introduces HD-Yolo, a deep learning method for faster and more accurate nuclei segmentation and tumor microenvironment quantification in whole-slide images.

A Multimodal Atlas of Tumor Metabolism Reveals the Architecture of Gene-Metabolite Co-regulation

The paper constructs a multimodal tumor metabolism atlas to identify gene-metabolite co-regulation patterns across cancer types.

SARS-CoV-2 exposure in Norway rats (Rattus norvegicus) from New York City

The paper tests SARS-CoV-2 exposure in NYC rats, finding 16.5% seropositive and partial genomes in some, and shows rat susceptibility to Alpha, Delta, and Omicron variants.

Initial niche condition determines the aging speed and regenerative activity of quiescent cells

This study shows that initial niche conditions determine the aging speed and regenerative activity of quiescent fission yeast cells, with regenerative activity declining linearly before survivability.

Recovery of structural integrity of epithelial monolayer in response to massive apoptosis-induced defects

This study shows that epithelial monolayers recover structural integrity after apoptosis-induced defects through enhanced cell spreading, migration, and traction forces.

Preferential cross-linking of the stereospecific complex over the encounter complexes by DOPA2, a faster cross-linker than DSS

This study compares DOPA2 and DSS cross-linkers, finding that faster cross-linking favors the stereospecific complex over encounter complexes in transient protein interactions.

A flexible, efficient, and scalable platform to produce circular RNAs as new therapeutics

This paper develops a self-catalyzed system to produce stable, low-immunogenic circRNAs for therapeutic protein expression, showing improved efficacy compared to linear mRNAs.

PP2A forestalls mitophagy by dephosphorylating Parkin and ubiquitin

This study identifies PP2A as a phosphatase that dephosphorylates Parkin and ubiquitin, thereby inhibiting mitophagy.

Spatially resolved profiling of protein conformation and interactions by biocompatible chemical cross-linking in living cells

This paper introduces SPACX, a method to profile protein conformation and interactions in living cells, revealing subcellular-specific heterogeneity and functional differences in PTEN.

Transcriptome features of trained immunity in Drosophila

This study investigates trained immunity in Drosophila by analyzing transcriptomic changes after bacterial infections, identifying distinct mechanisms for two bacteria.

Nucleobase clustering contributes to the formation and hollowing of repeat-expansion RNA condensate

This study shows that nucleobase clustering in RNA with repeat expansions leads to the formation and hollowing of RNA condensates, contributing to neurodegenerative disease mechanisms.

Flagellin FLiC Enhances Resistance of Upland Cotton to Verticillium dahliae

This study shows that flagellin FLiC enhances upland cotton resistance to Verticillium dahliae by inducing immune responses and modulating calcium, hydrogen peroxide, and nitric oxide pathways.

Systematic discovery of mutation-directed neo-protein-protein interactions in cancer

The paper identifies mutation-directed neo-protein-protein interactions in cancer using a high-throughput screening platform, revealing therapeutic opportunities through neo-interaction rewiring.

Azacytidine targeting SARS-CoV-2 viral RNA as a potential treatment for COVID-19

This study shows azacytidine limits SARS-CoV-2 infection and protects mice by disrupting viral RNA methylation.

Preferential interactions of a crowder protein with the specific binding site of a native protein complex

This paper investigates how crowder proteins affect the binding affinity and kinetics of the EIN-HPr protein complex using NMR and atomistic modeling, revealing preferential interactions that destabilize the complex.

Deep learning model of somatic hypermutation reveals importance of sequence context beyond targeting of AID and Polη hotspots

The paper develops a deep learning model to predict somatic hypermutation, showing that sequence context beyond AID and Polη hotspots significantly influences mutation patterns.

Genomic and Metabolic Hallmarks of SDH- and FH-Deficient Renal Cell Carcinomas

This study compares the genomic and metabolic features of SDH- and FH-deficient renal cell carcinomas, identifying distinct genetic and metabolic abnormalities.

Cell-to-cell variability in inducible Caspase9-mediated cell death

The paper investigates cell-to-cell variability in iCasp9-mediated cell death and identifies initial iCasp9 expression and XIAP/Caspase3 ratio as key factors, showing that combinatorial drugging can reduce drug resistance.