Author

P. Macklin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Microbiology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:trajectory inference· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

M. Getz· 2 shared A. Bakovic· 1 shared A. Madamanchi· 1 shared A. Magana· 1 shared A. N. F. Versypt· 1 shared A. Narayanan· 1 shared D. E. Conway· 1 shared D. M. Gilkes· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersBioengineering

M. Getz

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

An agent-based modeling approach for lung fibrosis in response to COVID-19

M. A. Islam, M. Getz, P. Macklin, A. N. F. Versypt

This paper develops an agent-based model to simulate lung fibrosis progression after SARS-CoV-2 infection, showing how TGF-β source dynamics influence fibrosis outcomes.

bioRxiv · Oct 3, 2022Bioengineering

A persistent invasive phenotype in post-hypoxic tumor cells is revealed by novel fate-mapping and computational modeling

H. L. Rocha, I. Godet, F. Kurtoglu, J. Metzcar, K. Konstantinopoulos, S. Bhoyar, D. M. Gilkes, P. Macklin

The paper uses fate-mapping and computational modeling to show that post-hypoxic tumor cells develop an invasive phenotype that promotes tumor expansion into oxygenated regions.

bioRxiv · Dec 30, 2020Cancer Biology

Maraviroc inhibits SARS-CoV-2 multiplication and s-protein mediated cell fusion in cell culture

K. Risner, K. V. Tieu, Y. Wang, M. Getz, A. Bakovic, N. Bhalla, S. Nathan, D. E. Conway, P. Macklin, A. Narayanan

This study identifies four FDA-approved drugs that inhibit SARS-CoV-2 infection in cell culture, with Maraviroc showing reduced S-protein mediated cell fusion.

bioRxiv · Aug 12, 2020 · PreprintMicrobiology

Supporting Computational Apprenticeship through educational and software infrastructure. A case study in a mathematical oncology research lab

A. Madamanchi, M. Thomas, A. Magana, R. Heiland, P. Macklin

This paper describes a case study of a computational biology lab using a computational apprenticeship framework to develop mentorship infrastructure for undergraduate research, focusing on cross-disciplinary training between mathematics, computation, and biology.

bioRxiv · Jul 31, 2020Scientific Communication & Education