N. Bhalla

Deferoxamine as adjunct therapeutics for tuberculosis

This study shows Deferoxamine (DFO) has antimycobacterial properties and can reduce Mtb burden when used as an adjunct to standard tuberculosis treatments.

The conserved AAA-ATPase PCH-2 distributes its regulation of meiotic prophase events by remodeling multiple meiotic HORMADs in C. elegans

This study shows PCH-2 remodels meiotic HORMADs in C. elegans to regulate homolog pairing, synapsis, and recombination, ensuring accurate meiotic progression.

Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for therapy

This study shows that Numb-associated kinases are essential for SARS-CoV-2 infection and that inhibiting them can suppress viral infection in human lung cells.

Low numbers of cytokine transcripts drive inflammatory skin diseases by initiating amplification cascades in localized epidermal clusters

Discovery of pan-ErbB inhibitors protecting from SARS-CoV-2 replication, inflammation, and lung injury by a drug repurposing screen

This study identifies lapatinib, an ErbB inhibitor, as a broad-spectrum antiviral that suppresses SARS-CoV-2 and VEEV replication, inflammation, and lung injury through ErbB-mediated mechanisms.

Mad1s ability to interact with Mad2 is essential to regulate and monitor meiotic synapsis in C. elegans

This study shows that Mad1's interaction with Mad2 is essential for regulating and monitoring meiotic synapsis in C. elegans, with Mad2 also binding other factors at the nuclear periphery.

Brilacidin, a COVID-19 Drug Candidate, Exhibits Potent In Vitro Antiviral Activity Against SARS-CoV-2

This paper shows brilacidin, a synthetic small molecule, strongly inhibits SARS-CoV-2 in cell cultures and works well with remdesivir.

Maraviroc inhibits SARS-CoV-2 multiplication and s-protein mediated cell fusion in cell culture

This study identifies four FDA-approved drugs that inhibit SARS-CoV-2 infection in cell culture, with Maraviroc showing reduced S-protein mediated cell fusion.

PCH-2TRIP13 regulates spindle checkpoint strength

This study shows that PCH-2/TRIP13 regulates spindle checkpoint strength in C. elegans by controlling Mad2 conformation and localization, particularly in germline precursor cells.

The transcriptional landscape of Venezuelan equine encephalitis virus (TC-83) infection

This study uses single-cell RNA sequencing to analyze the host and viral RNA dynamics during VEEV infection, identifying superproducer cells and candidate antiviral targets.

PCH-2 collaborates with CMT-1 to proofread meiotic homolog interactions

This study shows that PCH-2/TRIP13 proofreads meiotic homolog interactions with the help of CMT-1, ensuring proper synapsis and crossover assurance.

Cooperativity between the 3’ untranslated region microRNA binding sites is critical for the virulence of eastern equine encephalitis virus

This study shows that miR-142-3p binding sites in the 3' UTR of EEEV are critical for virulence, with both canonical and non-canonical sites contributing to virus replication and immune suppression.

Shugoshin is essential for meiotic prophase checkpoints in C. elegans

This study shows that SGO-1, the C. elegans Shugoshin ortholog, is essential for meiotic prophase checkpoints, with roles similar to HTP-3 in regulating chromosome structure and DNA repair pathways.