Cancer BiologybioRxivPreprint
Estrogen deprivation triggers an immunosuppressive phenotype in breast cancer cells
D. Huhn, P. Marti-Rodrigo, S. Mouron…·O. Fernandez-Capetillo
This study shows that estrogen deprivation in ER-positive breast cancer cells increases PD-L1 expression and triggers an immunosuppressive program, leading to resistance against T-cell killing.
DOI 10.1101/715136