Author

P. McDonald

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Organism:plant (other)· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Roy· 3 shared A. R. Fehr· 2 shared D. K. Johnson· 2 shared A. Leung· 1 shared A. R. A. Anderson· 1 shared D. V. Ferraris· 1 shared E. D. Holmstrom· 1 shared G. G. Poirier· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersBiochemistry

A. Roy

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Second-order effects of chemotherapy pharmacodynamics and pharmacokinetics on tumor regression and cachexia

L. Pierik, P. McDonald, A. R. A. Anderson, J. West

This study examines how varying chemotherapy dose schedules affect tumor regression and cachexia, finding that high variance schedules can improve outcomes without increasing total dose.

bioRxiv · Jun 14, 2023Cancer Biology

Discovery of small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase

S. Kaur, N. Nieto, P. McDonald, J. R. Beck, R. B. Honzatko, A. Roy, S. W. Nelson

The paper screens small-molecule libraries to identify inhibitors of Plasmodium falciparum apicoplast DNA polymerase, finding nine potent compounds that inhibit parasite growth.

bioRxiv · Mar 4, 2022Biochemistry

Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening

A. Roy, Y. M. Alhammad, P. McDonald, D. K. Johnson, J. Zhuo, S. Wazir, D. V. Ferraris, L. Lehtiö, A. Leung, A. R. Fehr

This study identifies 5 compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding through high-throughput screening, with IC50 values under 100 µM.

bioRxiv · Mar 1, 2022Biochemistry

The SARS-CoV-2 conserved macrodomain is a mono-ADP-ribosylhydrolase

Y. M. O. Alhammad, M. M. Kashipathy, A. Roy, J.-P. Gagne, P. McDonald, P. Gao, L. Nonfoux, K. P. Battaile, D. K. Johnson, E. D. Holmstrom, G. G. Poirier, S. W. Lovell, A. R. Fehr

This paper identifies SARS-CoV-2's Mac1 as a mono-ADP-ribosylhydrolase, showing it binds and hydrolyzes mono-ADP-ribose, with implications for antiviral therapy.

bioRxiv · May 11, 2020Biochemistry