Author

Y. M. O. Alhammad

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Organism:mouse· 1 Assay:structural biology· 1

Frequent Co-Authors

A. R. Fehr· 2 shared A. Roy· 1 shared C. Brenner· 1 shared C. D. Heer· 1 shared D. J. Sanderson· 1 shared D. K. Johnson· 1 shared E. D. Holmstrom· 1 shared G. G. Poirier· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

A. R. Fehr

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2 papers

Recent·Most cited

BiochemistrybioRxivMay 11, 2020

The SARS-CoV-2 conserved macrodomain is a mono-ADP-ribosylhydrolase

Y. M. O. Alhammad, M. M. Kashipathy, A. Roy…·A. R. Fehr

This paper identifies SARS-CoV-2's Mac1 as a mono-ADP-ribosylhydrolase, showing it binds and hydrolyzes mono-ADP-ribose, with implications for antiviral therapy.

DOI 10.1128/jvi.01969-20

humanstructural biology

𝕏 PostBluesky

MicrobiologybioRxivApr 17, 2020

Coronavirus infection and PARP expression dysregulate the NAD Metabolome: an actionable component of innate immunity

C. D. Heer, D. J. Sanderson, L. S. Voth…·C. Brenner

This study shows that SARS-CoV-2 infection upregulates MARylating PARPs and NAD synthesis enzymes, and that enhancing NAD levels can reduce viral replication.

DOI 10.1074/jbc.ra120.015138

mousebulk RNA-seq

𝕏 PostBluesky