MicrobiologybioRxivPreprint
Inhibition of host Lactate dehydrogenase A by a small-molecule limits Mycobacterium tuberculosis growth and potentiates bactericidal activity of isoniazid
G. Krishnamoorthy, P. Kaiser, U. Abu Abed…·S. H. E. Kaufmann
This paper shows that inhibiting host LDHA with FX11 limits M. tuberculosis growth and enhances the effectiveness of isoniazid in a mouse model of TB.
DOI 10.1101/626002