BiophysicsbioRxiv
Energetics of a protein disorder-order transition in small molecule recognition
C. Mendoza-Martinez, M. Papadourakis, s. llabres…·J. Michel
The paper investigates how a small molecule modulates a protein disorder-to-order transition, showing AM-7209 preferentially stabilizes ordered lid conformations in MDM2 compared to Nutlin-3a.
DOI 10.1039/d2sc00028h