Glucose deprivation promotes pseudo-hypoxia and de-differentiation in lung adenocarcinoma
P. Saggese, A. Pandey, E. Fung, A. Hall, J. Yanagawa, E. F. Rodriguez, T. R. Grogan, G. Giurato, G. Nassa, A. Salvati, A. Weisz, S. M. Dubinett, C. Scafoglio
This study shows glucose deprivation in lung adenocarcinoma causes de-differentiation and an aggressive phenotype through epigenetic changes and HIF1 activation.
bioRxiv · Jan 30, 2023Cancer Biology