J. Yanagawa

This study uses patient-derived tumor organoids to identify drug sensitivity and resistance patterns in sarcoma, finding actionable treatment regimens for 59% of tested specimens.

This study shows glucose deprivation in lung adenocarcinoma causes de-differentiation and an aggressive phenotype through epigenetic changes and HIF1 activation.

This study establishes patient-derived chordoma organoids to identify effective targeted therapies, finding PI3K/mTOR, EGFR, and JAK2/STAT3 inhibitors as promising candidates.

The paper uses single-cell RNA sequencing to compare immune and non-immune cell features in subsolid, solid, and non-involved lung tissues, finding reduced cytolytic activity and increased regulatory T cells in subsolid lesions.