BiochemistrybioRxiv
Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations
R. M. Counago, C. K. Allerston, P. Savitsky…·O. Gileadi
The paper identifies BI-D1870 as a starting point for VRK inhibitors and reports co-crystal structures revealing different P-loop conformations in VRK1 and VRK2.
DOI 10.1038/s41598-017-07755-y