Author

P. Selvakumar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Assay:electrophysiology· 1 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1

Frequent Co-Authors

A. I. Fernandez-Marino· 1 shared A. J. Gonzalez-Hernandez· 1 shared A. J. Paquette· 1 shared A. Strauss· 1 shared B. Melancon· 1 shared B. Wang· 1 shared C. He· 1 shared D. Marx· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

A. I. Fernandez-Marino

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Author profile →

3 papers

Recent·Most cited

Structural basis of allosteric modulation ofmetabotropic glutamate receptor activation and desensitization

A. Strauss, A. J. Gonzalez-Hernandez, J. Lee, N. Abreu, P. Selvakumar, L. Salas-Estrada, M. Kristt, D. Marx, K. Gilliland, B. Melancon, M. Filizola, J. Meyerson, J. Levitz

This study investigates how orthosteric and allosteric ligands affect mGluR activation and desensitization using electrophysiology, imaging, and cryo-EM structures.

bioRxiv · Aug 13, 2023 · PreprintBiophysics

Position-specific evolution in transcription factor binding sites, and a fast likelihood calculation for the F81 model

P. Selvakumar, R. Siddharthan

The paper introduces position-specific stationary vectors (PSSVs) for TFBS and presents a fast likelihood calculation for the F81 model to study evolutionary pressures.

bioRxiv · Jul 23, 2023Evolutionary Biology

Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators

P. Selvakumar, A. I. Fernandez-Marino, N. Khanra, C. He, A. J. Paquette, B. Wang, R. Huang, V. V. Smider, W. J. Rice, K. J. Swartz, J. R. Meyerson

This study determines the structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators, revealing two distinct mechanisms to suppress channel activity.

bioRxiv · Apr 19, 2022Biophysics