M. Filizola

This study investigates how orthosteric and allosteric ligands affect mGluR activation and desensitization using electrophysiology, imaging, and cryo-EM structures.

The paper develops a novel mitragynine analog with reduced mu-opioid receptor efficacy and adverse effects, showing antinociception without respiratory depression or hyperlocomotion.

This study presents high-resolution cryo-EM structures of 5-HT3AR-setron complexes, revealing distinct interaction fingerprints and a novel mechanism of competitive inhibition.

This study uses molecular dynamics simulations to investigate how magnesium ions bind to and modulate the μ-opioid receptor, revealing their role in stabilizing the activated state and enhancing opioid efficacy.

This paper designs and evaluates two small-molecule Vβ3 antagonists that inhibit cell adhesion and bone resorption without inducing receptor conformational changes or enhancing angiogenesis at low concentrations.

This paper develops a method combining metadynamics and maximum caliber to estimate thermodynamic and kinetic properties of GPCR activation efficiently.