C. He

A high resolution model of the grapevine leaf morphospace predicts synthetic leaves

The paper develops a high-resolution morphospace model of grapevine leaves to predict synthetic leaves and improve classification accuracy.

SMYD5 is a ribosomal methyltransferase that catalyzes RPL40 lysine methylation to enhance translation output and promote hepatocellular carcinoma

This study identifies SMYD5 as a methyltransferase that modifies RPL40 K22me3, enhancing translation and promoting hepatocellular carcinoma.

Dynamic regulation of H2A.Zub and H3K27me3 by ambient temperature in plant cell fate determination

The paper shows that low temperature restores developmental defects in PRC2 mutants by promoting H2A.Zub deposition at embryonic genes, compensating for H3K27me3 loss and silencing these genes for post-germination development.

Hypersensitivity of the vimentin cytoskeleton to net-charge states and Coulomb repulsion

This study shows that vimentin cytoskeleton assembly is sensitive to net charge states and Coulomb repulsion, with hypotonic stress causing rapid disassembly due to reduced charge screening.

Skeleton-forming responses of reef-building corals under ocean acidification

This study examines how four coral species form skeletons under acidified conditions, revealing diverse strategies and damage patterns.

Genome Assembly of Docynia delavayi Provides New Insights into α-Farnesene Biosynthesis

This study reports the first high-quality genome of Docynia delavayi and identifies key genes and transcription factors involved in α-farnesene biosynthesis, a major aroma compound in its fruit.

Short-Term Disruption of TGFβ Signaling in Adult Mice Renders the Aorta Vulnerable to Hypertension-Induced Dissection

This study shows that disrupting TGFβ signaling in adult mice makes the aorta susceptible to hypertension-induced dissection, even from short-term blood pressure increases.

Dynamics of RNA localization to nuclear speckles are connected to splicing efficiency

The paper investigates RNA localization to nuclear speckles and finds that splicing efficiency is linked to transcript enrichment in these organelles.

Is myeloid-derived growth factor a ligand of the sphingosine-1-phosphate receptor 2?

The paper tests if MYDGF is a ligand for S1PR2 using functional assays and finds it is not.

Granulosa cell-layer stiffening prevents the granulosa cells from escaping the post-ovulatory follicle

The paper shows that granulosa cell-layer stiffening, driven by focal adhesion assembly and LH signaling, prevents granulosa cells from escaping the post-ovulatory follicle.

Unveiling the regulatory role of GRP7 in ABA signal-mediated mRNA translation efficiency regulation

This study identifies GRP7 as a key regulator of ABA-mediated translation efficiency in Arabidopsis by modulating pre-rRNA processing and ribosome distribution.

Genomic signatures associated with the evolutionary loss of egg yolk in parasitoid wasps

This study identifies genomic signatures of yolk loss in parasitoid wasps, showing independent Vg gene loss events and associated functional biases in related genes.

Low albumin status accompanies multi-layered immunosuppressive phenotypes in metastatic breast cancer patients

The paper investigates the association between low albumin levels and immunosuppressive phenotypes in metastatic breast cancer patients using transcriptomic and metabolomic data.

PTPN2 copper-sensing rapidly relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression

The paper identifies PTPN2 as a copper sensor that modulates EGFR/CREB signaling and CTR1 transcriptional repression in response to copper level changes.

Borg extrachromosomal elements of methane-oxidizing archaea have conserved and expressed genetic repertoires

The paper identifies conserved genetic repertoires in Borg extrachromosomal elements of methane-oxidizing archaea and shows their higher expression than host genes.

Multidimensional super-resolution microscopy unveils nanoscale surface aggregates in the aging of FUS condensates

This study uses multidimensional super-resolution microscopy to reveal nanoscale surface aggregates in aging FUS condensates and their impact on diffusion.

T-cell inflammation is prognostic of survival in patients with high-risk neuroblastoma enriched for an adrenergic signature

The paper identifies T-cell inflammation (TCI) as a prognostic marker in high-risk neuroblastoma, showing improved survival in ADRN tumors but not MES tumors.

Enzyme-mediated alkynylation enables transcriptome-wide identification of pseudouridine modifications

The paper introduces ELAP-seq, a method to detect pseudouridine modifications in RNA with high sensitivity and resolution, identifying over 10,000 sites in human transcripts.

m6A mRNA Methylation in Brown Adipose Tissue Regulates Systemic Insulin Sensitivity via an Inter-Organ Prostaglandin Signaling Axis

Dynamics of the epigenetic landscape during development and in response to drought stress in sorghum

This study identifies novel epigenomic features in sorghum, including H3K27me3 islands and the role of histone marks in regulating tissue-specific and stress-responsive genes.

Senescence triggers intracellular acidification and lysosomal alkalinization via ATP6AP2 attenuation in breast cancer cells

This study shows that ATP6AP2 downregulation in senescent breast cancer cells causes pH dysregulation, impairing lysosome function and altering immune responses.

Induction of transmucosal protection by oral vaccination with an attenuated Chlamydia

This study evaluates an attenuated Chlamydia muridarum mutant as an oral vaccine that induces transmucosal immunity against genital and airway infections but not gastrointestinal colonization.

TERT accelerates BRAF mutant-induced thyroid cancer dedifferentiation and progression by regulating ribosome biogenesis

This study shows TERT promotes thyroid cancer dedifferentiation and progression by enhancing ribosome biogenesis, and inhibiting rRNA synthesis can reverse this process.

Cdkn2a regulates beige fat maintenance through BECN1-mediated autophagy

This study shows that Cdkn2a regulates beige fat maintenance via BECN1-mediated autophagy, with implications for obesity and diabetes treatment.

YAP1 is essential for self-organized differentiation of pluripotent stem cells

This study shows YAP1 is critical for germ layer specification in iPSCs, particularly in self-organized embryoid bodies, through NODAL pathway activation.

TRAF6 modulates PD-L1 expression through YAP1-TFCP2 signaling in melanoma

This study identifies TRAF6 as a regulator of PD-L1 expression in melanoma through YAP1-TFCP2 signaling, showing TRAF6 inhibition enhances anti-tumor immunity.

Serum amyloid alpha 1-2 are not required for systemic inflammation in the 4T1 murine breast cancer model

This study shows that SAA1-2 proteins are not essential for systemic inflammation in the 4T1 murine breast cancer model.

Initial niche condition determines the aging speed and regenerative activity of quiescent cells

This study shows that initial niche conditions determine the aging speed and regenerative activity of quiescent fission yeast cells, with regenerative activity declining linearly before survivability.

Underlying beneficial effects of Rhubarb on constipation-induced inflammation, disorder of gut microbiome and metabolism

This study investigates rhubarb's effects on constipation-induced inflammation, gut microbiome, and metabolism in mice, showing improvements in cytokine balance, microbial diversity, and fatty acid metabolism.

Pathogen-Host Adhesion between SARS-CoV-2 S Proteins from Different Variants and Human ACE2 Probed at Single-Molecule and Single-Cell Levels

This study investigates the adhesion of SARS-CoV-2 S proteins from different variants to human ACE2 using single-molecule and single-cell force spectroscopy, finding Delta variant has the highest binding affinity.