The Ca2+-gated Cl- channel TMEM16A amplifies capillary pericyte contraction reducing cerebral blood flow after ischemia
N. Korte, Z. Ilkan, C. Pearson, T. Pfeiffer, P. Singhal, J. Rock, H. Sethi, D. Gill, D. Attwell, P. Tammaro
This study shows that TMEM16A in pericytes amplifies capillary constriction and reduces cerebral blood flow after ischemia, suggesting it as a therapeutic target for stroke and related disorders.
bioRxiv · Feb 3, 2022 · PreprintPhysiology