Author

C. Pearson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 6 Research Focus:cell type annotation· 4 Research Focus:cell signaling & trafficking· 3 Assay:bulk RNA-seq· 2 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

E. E. Thornton· 3 shared F. Powrie· 3 shared Y. Gu· 3 shared A. Janney· 2 shared B. Seddon· 2 shared C. Heuberger· 2 shared M. Friedrich· 2 shared N. Ilott· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersImmunology

E. E. Thornton

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T cell responses

C. Heuberger, A. Janney, N. Ilott, A. Bertocchi, S. Pott, Y. Gu, M. Pohin, M. Friedrich, E. Mann, C. Pearson, F. Powrie, J. Pott, E. E. Thornton, K. J. Maloy

This study shows that intestinal epithelial cells expressing MHC II modulate CD4 T cell responses during intestinal inflammation, dampening pro-inflammatory effector Th cells.

bioRxiv · Jan 23, 2023Immunology

A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice

C.-P. Hackstein, D. Costigan, L. Drexhage, C. Pearson, S. Bullers, N. Ilott, H. D. Akther, Y. Gu, M. E. B. FitzPatrick, O. J. Harrison, L. C. Garner, E. H. Mann, S. Pandey, M. Friedrich, N. M. Provine, , E. E. Thornton

The paper identifies a conserved population of MHC-II restricted, innate-like T cells in the gut of humans and mice that react to commensals and are implicated in colitis.

bioRxiv · Sep 26, 2022 · PreprintImmunology

Intestinal lamina propria supports acquired eTreg suppressor function

Y. Gu, R. Bartolome-Casado, C. Xu, A. Janney, C. Heuberger, C. Pearson, S. Teichmann, E. E. Thornton, F. Powrie

This study identifies spatially compartmentalized Treg subsets in the gut, showing that lamina propria supports acquired eTreg suppressor function through specific interactions with IL-1β+ macrophages and ILC2.

bioRxiv · Aug 26, 2022 · PreprintImmunology

The Ca2+-gated Cl- channel TMEM16A amplifies capillary pericyte contraction reducing cerebral blood flow after ischemia

N. Korte, Z. Ilkan, C. Pearson, T. Pfeiffer, P. Singhal, J. Rock, H. Sethi, D. Gill, D. Attwell, P. Tammaro

This study shows that TMEM16A in pericytes amplifies capillary constriction and reduces cerebral blood flow after ischemia, suggesting it as a therapeutic target for stroke and related disorders.

bioRxiv · Feb 3, 2022 · PreprintPhysiology

The SON RNA splicing factor is required for intracellular trafficking that promotes centriole assembly

A. J. Stemm-Wolf, E. T. O'Toole, R. M. Sheridan, J. T. Morgan, C. Pearson

This study identifies SON as an RNA splicing factor essential for centriole assembly by regulating CEP131 splicing and expression, which is critical for microtubule trafficking and centrosome function.

bioRxiv · Jan 29, 2021Cell Biology

Fate mapping quantifies the dynamics of B cell development and activation throughout life

M. Verheijen, S. Rane, C. Pearson, A. J. Yates, B. Seddon

This study uses fate mapping in mice to show differences in B cell dynamics between follicular and germinal center cells across life.

bioRxiv · Feb 25, 2020Immunology

Differential impact of self and environmental antigens on the ontogeny and maintenance of CD4+ T cell memory

T. Hogan, M. Nowicka, D. Cownden, C. Pearson, A. Yates, B. Seddon

This study investigates how self and environmental antigens influence the development and maintenance of CD4+ T cell memory in mice, showing early environmental exposure shapes memory populations, while later replenishment is environment-independent.

bioRxiv · Nov 19, 2019Immunology