An original model of brain infection identifies the hijacking of host lipoprotein import as a bacterial strategy for blood-brain barrier crossing.
B. Benmimoun, F. Papastefanaki, B. Perichon, K. Segklia, N. Roby, V. Miriagou, C. Schmitt, R. Matsas, S. Dramsi, P. Speder
The paper identifies lipoprotein import hijacking as a bacterial strategy for crossing the blood-brain barrier using a Drosophila model and validates it in a murine system.
bioRxiv · Feb 28, 2020 · PreprintMicrobiology