S. Dramsi

Induction of intercrypt goblet cells upon bacterial infection

This study shows that bacterial infection induces intercrypt goblet cells (icGCs) in mice, which produce a protective mucus layer with unique glycosylation that blocks pathogens.

Transcriptome profiling of human colonic cells exposed to the gut pathobiont Streptococcus gallolyticus subsp. gallolyticus.

This study profiles the transcriptome of human colonic cells exposed to SGG, showing it induces stronger transcriptional changes in cancerous HT29 cells than in normal FHC cells, with significant ER stress and UPR activation.

The oncogenic role of Streptococcus gallolyticus subsp. gallolyticus is linked to activation of multiple cancer-related signaling pathways

This study shows that SGG UCN34 promotes colon cancer by activating multiple cancer-related signaling pathways through proteomic and phosphoproteomic analyses in mice and human tumors.

Gallocin A, an atypical two-peptide bacteriocin with intramolecular disulfide bonds required for activity

This paper characterizes gallocin A, a two-peptide bacteriocin from SGG, showing it requires intramolecular disulfide bonds for activity and that its immunity peptide shares structural features with the toxin.

Characterization of TelE, an LXG effector exhibiting a conserved C-terminal glycine zipper motif required for toxicity

The paper identifies and characterizes TelE, an LXG effector from SGG with pore-forming activity, showing its toxicity and requirement for a conserved glycine zipper motif.

Secretion, maturation and activity of a quorum-sensing peptide (GSP) inducing bacteriocins transcription in Streptococcus gallolyticus

This paper investigates the processing, export, and structure-activity relationship of GSP, a quorum-sensing peptide in Streptococcus gallolyticus that activates bacteriocin production.

Bacteriocin production in Streptococcus gallolyticus by a complex 4-component regulatory system with activator and anti-activator activities

This paper identifies a 4-component regulatory system in Streptococcus gallolyticus that controls gallocin production through activator and anti-activator proteins.

An original model of brain infection identifies the hijacking of host lipoprotein import as a bacterial strategy for blood-brain barrier crossing.

The paper identifies lipoprotein import hijacking as a bacterial strategy for crossing the blood-brain barrier using a Drosophila model and validates it in a murine system.

Heterogeneous expression of Pil3 pilus is critical for Streptococcus gallolyticus translocation across polarized colonic epithelial monolayers

This paper shows that heterogeneous Pil3 pilus expression in Streptococcus gallolyticus enables translocation across intestinal epithelial barriers.