C. Schmitt

Genetically modified IL-2 bone marrow-derived myeloid cells reprogram the glioma immunosuppressive tumormicroenvironment

This study shows that genetically modified myeloid cells releasing IL-2 can reprogram the glioma tumor microenvironment to enhance anti-tumor immunity in a mouse model.

Amplicon structure creates collateral therapeutic vulnerability in cancer

The paper identifies DDX1 as a passenger gene co-amplified with MYCN in cancer, showing that its aberrant expression creates a therapeutic vulnerability through mTORC1 dependency.

Strigo-D2 - a bio-sensor for monitoring the spatio-temporal pattern of strigolactone signaling in intact plants

The paper introduces Strigo-D2, a genetically encoded sensor to monitor strigolactone signaling in plants, showing differential dynamics across cell types.

Directed Evolution of AAV Targeting Primate Retina by Intravitreal Injection Identifies R100, a Variant Demonstrating Robust Gene Delivery and Therapeutic Efficacy in Non-Human Primates

An original model of brain infection identifies the hijacking of host lipoprotein import as a bacterial strategy for blood-brain barrier crossing.

The paper identifies lipoprotein import hijacking as a bacterial strategy for crossing the blood-brain barrier using a Drosophila model and validates it in a murine system.

Ancient hybridization and strong adaptation to viruses across African vervet monkey populations

This study analyzes genome-wide polymorphism in vervet monkeys to reveal ancient hybridization and strong adaptation to viruses, particularly SIV, across African populations.