GDF15 and the beneficial actions of metformin in pre-diabetes
A. P. Coll, M. Chen, P. Taskar, D. Rimmington, S. Patel, J. Tadross, I. Cimino, M. Yang, P. Welsh, S. Virtue, D. A. Goldspink, E. Miedzybrodzka, Y. C. L. Tung, S. Rodriguez-Cuenca, R. A. Tomaz, , S. O'Rahilly
This study shows metformin increases GDF15 levels, which is necessary for its weight loss and insulin-sensitizing effects in both humans and mice.
bioRxiv · Jun 21, 2019Physiology