Modeling PPRV pathogenesis in mice to assess the contribution of innate cells and anti-viral T cells
Y. Sharma, R. Sarkar, A. Jain, S. Singh, C. Shekhar, C. Shanmugam, M. Dhanavelu, P. Tembure, R. Kaul, S. Sehrawat
This study establishes a mouse model to investigate PPRV pathogenesis, showing that IFNR KO mice succumb to infection regardless of dose, with neutrophils/macrophages transporting virus to CNS and CD8+ T cells providing protection.
bioRxiv · Oct 27, 2020 · PreprintImmunology