Y. Sharma

Dissecting the Ca2+ dependence of Mycobacterium tuberculosis DesA1 function

This study investigates the role of Ca2+ in Mycobacterium tuberculosis DesA1 function, showing that Ca2+ binding stabilizes the protein and is essential for its activity and resistance to isoniazid.

Reward quantity discrimination in an associative learning task in wild zebrafish (Danio rerio)

This study tests reward quantity discrimination in wild zebrafish using an operant conditioning task and finds some fish can discriminate between stimuli associated with different rewards.

Close-kin mark-recapture methods to estimate demographic parameters of mosquitoes

This paper extends close-kin mark-recapture methods to mosquitoes, showing they can accurately estimate demographic parameters like population size and mortality rates using genetic data from simulated populations.

A human stem cell resource to decipher the biochemical and cellular basis of neurodevelopmental defects in Lowe Syndrome

This study generates human stem cell lines from Lowe Syndrome patients to investigate the cellular and biochemical mechanisms of brain development defects caused by OCRL1 mutations.

Proteogenomics Reveals how Metastatic Melanoma Modulates the Immune System to Allow Immune Evasion

This paper analyzes proteogenomic data from melanoma patients to show how metastatic melanoma alters metabolism and immune responses to evade immune detection.

In vitro infection of human lung tissue with SARS-CoV-2: Heterogeneity in host defense and therapeutic response

This paper develops an in vitro model using cryopreserved human lung tissue to study SARS-CoV-2 infection and drug responses, revealing donor-specific heterogeneity in viral susceptibility and treatment outcomes.

Modeling PPRV pathogenesis in mice to assess the contribution of innate cells and anti-viral T cells

This study establishes a mouse model to investigate PPRV pathogenesis, showing that IFNR KO mice succumb to infection regardless of dose, with neutrophils/macrophages transporting virus to CNS and CD8+ T cells providing protection.

Breast tumors escape endocrine therapy by ER-independent mechanisms triggered by the coordinated activities of HER2/HER3 and deacetylated FOXA1

This study shows that HER2/HER3 signaling and FOXA1 deacetylation drive ER-independent growth in hormone-resistant breast tumors by altering FOXA1 chromatin binding and function.

Tumor invasion as non-equilibrium phase separation

The paper shows tumor spheroids exhibit solid-like, fluid-like, and gas-like phases during invasion, with phase transitions influenced by cell type and matrix density.

Robustness of early warning signals for catastrophic and non-catastrophic transitions

This study tests the effectiveness of early warning signals for different types of ecological regime shifts under various noise conditions and finds they work well for saddle-node bifurcations but not others.

SCGN Administration prevents Insulin Resistance and Diabetic Complications in High-Fat Diet Fed Animals

This study shows that administering SCGN improves insulin response and alleviates diabetic complications in high-fat diet-fed animals.