BET inhibitors as a therapeutic intervention in gastrointestinal gene signature-positive castration-resistant prostate cancer.
S. Shukla, D. Li, H. Nguyen, J. Conner, G. Bayshtok, W. H. Cho, M. Pachai, N. Teri, E. Campeau, S. Attwell, P. Trojer, I. Ostrovnaya, A. Gopalan, E. Corey, P. Chi, Y. Chen
This study identifies BET inhibitors as effective against GI transcriptome-positive CRPC by targeting HNF1A and HNF4G, improving outcomes in preclinical models.
bioRxiv · Mar 9, 2024 · PreprintCancer Biology