Vps18 contributes to phagosome membrane integrity in Mycobacterium tuberculosis-infected macrophages.
C. Jani, A. Marsh, P. Uchil, N. Jain, Z. R. Baskir, O. Glover, D. E. Root, J. G. Doench, A. K. Barczak
This study identifies Vps18 as a host factor critical for maintaining phagosomal membrane integrity in Mtb-infected macrophages, showing increased phagosomal damage and reduced antibiotic efficacy in its absence.
bioRxiv · Oct 1, 2023 · PreprintMicrobiology