BiochemistrybioRxiv
The reactivity of an unusual amidase may explain colibactin’s DNA cross-linking activity
Y. Jiang, A. Stornetta, P. W. Villalta…·E. P. Balskus
This paper identifies ClbL as an amidase enzyme that forms amide bonds, contributing to colibactin's DNA cross-linking activity by incorporating electrophilic warheads into its structure.
DOI 10.1021/jacs.9b02453