Mannose-coupled AAV2: a second generation AAV vector for increased retinal gene therapy efficiency
M. MEVEL, V. Pichard, M. Bouzelha, D. Alvarez-Dorta, P.-A. Lalys, N. Provost, M. Allais, A. Mendes, E. Landagaray, J.-B. Ducloyer, A. Galy, N. Brument, G. M. Lefevre, S. G. Gouin, C. Isiegas, , O. Adjali
This study develops a modified AAV vector with increased transduction efficiency in retinas of rats and nonhuman primates by covalently attaching mannose ligands.
bioRxiv · Dec 1, 2022Bioengineering