A. Galy

Cellular Immune Responses Induced by Subretinal AAV Gene Transfer can be Restrained by the Subretinal Associated Immune Inhibition Mechanism

This study shows that subretinal AAV8 injection induces proinflammatory T-cell responses against transgene products, which can be modulated by the subretinal associated immune inhibition mechanism.

Mannose-coupled AAV2: a second generation AAV vector for increased retinal gene therapy efficiency

This study develops a modified AAV vector with increased transduction efficiency in retinas of rats and nonhuman primates by covalently attaching mannose ligands.

Single-hit genome edition for expression of single-chain immunoglobulins by edited B cells

This paper develops a method to redirect B cells to express single-chain immunoglobulins by editing a single genomic locus, validated in cell lines and primary B cells.

Syncytins enable novel possibilities to transduce human or mouse primary B cells and to achieve well-tolerated in vivo gene transfer

This paper demonstrates that syncytins can pseudotype lentiviral vectors for efficient B cell transduction and reduced in vivo immunogenicity.