BioengineeringbioRxiv
Mannose-coupled AAV2: a second generation AAV vector for increased retinal gene therapy efficiency
M. MEVEL, V. Pichard, M. Bouzelha…·O. Adjali
This study develops a modified AAV vector with increased transduction efficiency in retinas of rats and nonhuman primates by covalently attaching mannose ligands.
DOI 10.1016/j.omtm.2024.101187