P.-F. Lenne

Fast volumetric fluorescence lifetime imaging of multicellular systems using single-objective light-sheet microscopy

This paper accelerates fluorescence lifetime imaging (FLIM) using single-objective light-sheet microscopy, achieving faster and less phototoxic imaging of live multicellular systems.

Marangoni-like tissue flows enhance symmetry breaking of embryonic organoids

The paper shows that tissue mechanics, specifically Marangoni-like flows, drive symmetry breaking in mouse embryonic organoids, establishing a primary axis through differential surface tension.

Two-point optical manipulation reveals mechanosensitive remodeling of cell-cell contacts in vivo

This paper develops an optical manipulation technique to study mechanosensitive remodeling of cell-cell contacts in Drosophila embryos and identifies mechanosensitive feedback mechanisms.

Super-resolution imaging uncovers the nanoscopic segregation of polarity proteins in epithelia

The paper uses super-resolution imaging to reveal the nanoscale organization of polarity proteins in epithelial cells, showing segregated clusters and specific spatial relationships.

Nectins rather than E-cadherin anchor the actin belts at cell-cell junctions of epithelia

This study uses super-resolution microscopy to show that nectins, not E-cadherin, anchor actin belts at cell-cell junctions in epithelia, redefining the structure of the zonula adherens.

Force inference predicts local and tissue-scale stress patterns in epithelia

This study validates force inference as a reliable method to predict force patterns in Drosophila epithelia by comparing it with laser ablation experiments.

Distinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis

The paper investigates how tensile and shear stresses affect E-cadherin levels during Drosophila embryo axis elongation, finding distinct impacts on adhesion.

Coupling of Rho family GTPases during mesenchymal-to-epithelial-like transitions

The paper shows how Rac and Rho GTPases are regulated during mesenchymal-to-epithelial transitions in Drosophila dorsal closure, highlighting the role of elmo-dock and arhgap21.