Transthyretin Contributes to Hippocampal Blood-Brain Barrier Recovery Following Intestinal Inflammation, with Reduced Expression in Alzheimer's Disease
Zhi Xu, Jun Chen, Jiayi Yu, Jing Duan, Yazhou Xie, Yuqi Gong, Pan Wang, Xia Lei, Can Zhang, Xiaoduo Zhao, Zhongqin Fan, Bin Xu, Jing Zhang
The paper investigates how intestinal inflammation affects the blood-brain barrier (BBB) and identifies transthyretin (TTR) as a key factor in BBB recovery, with reduced TTR expression linked to Alzheimer's disease.
bioRxiv · Sep 4, 2026 · PreprintNeuroscience