Molecular BiologybioRxivPreprint
Cell-resolved pharmacodynamic profiling reveals tissue- and cell-population-specific activity of antisense oligonucleotide chemical conjugates in vivo
Shuzhi Cheng, Jennifer Frommer, Ayad Eddaoudi…·Haiyan Zhou
This study evaluates cell-specific activity of antisense oligonucleotide conjugates in vivo using a reporter mouse model and finds that palmitate conjugation shows broad extrahepatic activity and preferential skeletal muscle targeting.
DOI 10.64898/2026.10.30.762893