Pharmacology & ToxicologybioRxivPreprint
Target validation uncouples TSPO from 19-Atriol-mediated inhibition of steroidogenesis and reveals true enzymatic targets
Amy H. Zhao, Prasanthi P. Koganti, Mingxing Qian…·Vimal Selvaraj
This study shows 19-Atriol inhibits steroidogenesis by directly targeting 3β-HSD and other enzymes, not via TSPO, resolving a long-standing mechanistic confusion.
DOI 10.1101/2025.09.25.678677