Judith Simcox

This study optimizes LC-MS methods for oxylipin quantification in human plasma by using bio-inert systems and adjusting ion funnel voltages, improving signal and compound detection.

This study shows that acetyl-CoA availability, regulated by AT-1, affects neuronal metabolism, growth, and synaptic activity in mice.

This study shows that Stearoyl-CoA Desaturases (SCDs) regulate intestinal stem and progenitor cell metabolism and function in response to nutrient abundance, affecting tissue homeostasis and regeneration.

This study shows that reducing dietary isoleucine improves metabolic health in mice on a Western diet, with distinct molecular responses across sexes and strains.

This study identifies ACAD10 as encoding two enzymes involved in ether lipid biosynthesis and salvage, linking them to type 2 diabetes risk.

This study identifies ACAD10 and ACAD11 as enzymes critical for metabolizing 4-hydroxy fatty acids in mammals, revealing their unique mechanisms and subcellular localization.

The paper shows dietary lipid is deposited in skin, altering its thermal properties and energy regulation within days.

The paper identifies TFEB regulation of BMP lipid catabolism via Pla2g15, showing increased BMP lipids in Pla2g15 knockout mice and cold intolerance upon TFEB knockdown.

This study identifies PLA2G15 as a lysosomal BMP hydrolase and shows its targeting improves lysosomal disease symptoms in NPC1 models.

This study shows how human gut microbiota interactions influence the long-term growth and evolutionary adaptations of C. difficile, including metabolic shifts and reduced disease severity.

This study shows that MBOAT7 loss of function in hepatocytes causes ethanol-induced liver injury by disrupting lysosomal biogenesis and autophagic flux.

This study identifies HNF4a's role in regulating acyl chain remodeling and ether lipid accumulation in hepatic steatosis through cold stress-induced changes in lipid metabolism.

This study shows that loss of TLE3 enhances mitochondrial function in beige adipocytes, improves glucose metabolism, and prevents weight gain.