ImmunologyNature CommunicationsPeer-reviewed
CD4+ T-cells create a stable mechanical environment for force-sensitive TCR:pMHC interactions
Lukas Schrangl, Florian Kellner, René Platzer…·Janett Göhring
The paper quantifies mechanical forces on TCR:pMHC interactions in CD4+ T-cells, finding low forces that do not affect bond lifetimes, suggesting the immunological synapse stabilizes antigen recognition.