BiochemistryThe EMBO JournalPeer-reviewed
Elucidating the activation mechanism for GBP1 oligomerization
Marius Weismehl, Xiaofeng Chu, Miriam Kutsch…·Oliver Daumke
This study reveals the activation mechanism of GBP1 oligomerization through cryo-EM structures, showing nucleotide-dependent conformational changes drive dimerization, oligomerization, and membrane binding for pathogen encapsulation.