Molecular BiologybioRxivPreprint
Cardiomyocyte-specific deletion of PTP1B protects against HFD-induced cardiomyopathy through direct regulation of cardiac metabolic signaling
Yan Sun, Vasanth Chanrasekhar, Chase W. Kessinger…·Maria Irene Kontaridis
This study shows that deleting PTP1B in cardiomyocytes protects against high-fat diet-induced heart disease by promoting fatty acid metabolism and reducing glucose metabolism through a novel PTP1B/PKM2/AMPK axis.
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