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PHE Virology Consortium

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:proteomics· 1 Research Focus:variant effect prediction· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

J. C. Brown· 2 shared J. Zhou· 2 shared N. Goonawardane· 2 shared T. P. Peacock· 2 shared W. S. Barclay· 2 shared A. Pinto· 1 shared A. Singanayagam· 1 shared C. M. Sheppard· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersMicrobiology

J. C. Brown

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintMay 28, 2021

The SARS-CoV-2 variants associated with infections in India, B.1.617, show enhanced spike cleavage by furin

T. P. Peacock, C. M. Sheppard, J. C. Brown…·W. S. Barclay

This study shows SARS-CoV-2 B.1.617 variants have enhanced spike cleavage by furin due to the P681R mutation, potentially increasing transmissibility and pathogenicity.

DOI 10.1101/2021.05.28.446163

humanexperimental assay

𝕏 PostBluesky

MicrobiologybioRxivPreprintFeb 24, 2021

Increased transmission of SARS-CoV-2 lineage B.1.1.7 (VOC 2020212/01) is not accounted for by a replicative advantage in primary airway cells or antibody escape

J. C. Brown, D. H. Goldhill, J. Zhou…·W. S. Barclay

This study shows that SARS-CoV-2 variant B.1.1.7 does not replicate better in airway cells or escape antibodies, suggesting its increased transmissibility is due to other factors.

DOI 10.1101/2021.02.24.432576

humanbulk RNA-seq

𝕏 PostBluesky