Systems BiologyJournal of Biological ChemistryPeer-reviewed
NADPH consumption by L-cystine reduction creates a metabolic vulnerability upon glucose deprivation
James H. Joly, Alireza Delfarah, Philip S. Phung…·Nicholas Alexander Graham
The paper identifies L-cystine reduction as a metabolic vulnerability in cancer cells under glucose deprivation and proposes co-targeting GLUT1 and glutathione synthesis as a therapeutic strategy.
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