ImmunologybioRxivPreprint
Epigenetic control of S100A8/A9-driven monocytic inflammation licenses anti-leukemic functionality of immature NK cells during hematopoietic stem cell differentiation.
Ronja Larissa Schirrmann, Daniel Stowitschek, Malika Franziska Sutter…·Maya Caroline Andre
This study shows that epigenetic priming of healthy donor CD34+ stem cells drives S100A8/A9-driven inflammation, enhancing NK cell anti-leukemic activity during hematopoietic differentiation and improving response to 5-AzaC therapy in MDS.
DOI 10.64898/2026.03.25.714180