Cell BiologybioRxivPreprint
SERPINE1-AP2A1 interplay links substrate stiffness to fibroblast senescence
Intan Chairun Nisa, Pirawan Chantachotikul, Takumi Saito…·Shinji Deguchi
This study shows that substrate stiffness influences fibroblast senescence through the SERPINE1-AP2A1 interaction, affecting cytoskeletal remodeling and senescence-associated secretory phenotype factors.
DOI 10.64898/2026.06.30.735455