Cancer BiologybioRxiv
Microenvironmental variables must influence intrinsic phenotypic parameters of cancer stem cells to affect tumourigenicity
Jacob Scott, Anita Hjelmeland, Prakash Chinnaiyan…·David Basanta
The paper develops a computational model to study how microenvironmental factors influence cancer stem cell phenotypes and tumour growth, finding that microenvironmental variables have limited impact and that intrinsic parameters are more critical.
DOI 10.1371/journal.pcbi.1003433