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Pratikshya Pandey

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Synthetic Biology· 1

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Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Approach:statistical model· 1

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Alex William HewittiD· 1 shared Alexander J. BarnettiD· 1 shared Kirsten A. FairfaxiD· 1 shared Pamodha SomasiriiD· 1 shared Rajendra KCiD· 1 shared

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Synthetic BiologybioRxivPreprintMar 23, 2025

Systematic comparison of Generative AI-Protein Models reveals fundamental differences between structural and sequence-based approaches.

Alexander J. Barnett, Rajendra KC, Pratikshya Pandey…·Alex William Hewitt

This study compares generative AI models for protein design, finding structural models produce more confident structures but less diversity, while language models generate more diverse proteins with lower structural confidence.

3 citations

protein sequencedeep learning

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