Author

Q. Faucher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Approach:deep learning· 2 Approach:statistical model· 2 Assay:structural biology· 2 Approach:experimental assay· 1 Assay:metabolomics· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

P. Marquet· 4 shared F. Di Meo· 3 shared H. Arnion· 3 shared A. Janaszkiewicz· 2 shared A. Toth· 2 shared C. Barin-Le Guellec· 2 shared F.-L. SAUVAGE· 2 shared M. ESSIG· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersPharmacology & Toxicology

P. Marquet

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4 papers

Recent·Most cited

Substrate binding and lipid-mediated allostery in the human organic anion transporter 1 at the atomic-scale

A. Janaszkiewicz, A. Toth, Q. Faucher, H. Arnion, N. Vedrenne, C. Barin-Le Guellec, P. Marquet, F. Di Meo

This study investigates the structure and function of hOAT1 using molecular dynamics simulations, identifying substrate binding sites and allosteric mechanisms involving lipid interactions.

bioRxiv · Jul 14, 2022Pharmacology & Toxicology

Insights into the structure and function of the human organic anion transporter 1 in lipid bilayer membranes

A. Janaszkiewicz, A. Toth, Q. Faucher, M. Martin, B. Chantemargue, C. Barin-Le Guellec, P. Marquet, F. Di Meo

This study presents the first robust model of hOAT1 in outward-facing conformation using protein-threading and MD simulations, revealing structural and functional insights into its transport mechanism.

Scientific Reports · Apr 29, 2022Peer-reviewedPharmacology & Toxicology

Multi-omics investigation of tacrolimus nephrotoxicity

H. AOUAD, Q. FAUCHER, F.-L. SAUVAGE, E. PINAULT, C.-C. BARROT, H. ARNION, P. MARQUET, M. ESSIG

This study investigates tacrolimus nephrotoxicity in LLC-PK1 cells using multi-omics analysis, revealing metabolic pathway disruptions and oxidative stress.

bioRxiv · Jul 29, 2021 · PreprintPharmacology & Toxicology

Cyclosporine A inhibits MRTF-SRF signalling through Na+/K+ ATPase inhibition & Actin remodelling

B. Burat, Q. Faucher, P. Cechova, H. Arnion, F. Di Meo, F.-L. Sauvage, P. Marquet, M. Essig

This study identifies a novel pathway by which Cyclosporine A causes nephrotoxicity through Na+/K+-ATPase inhibition and Actin remodelling in renal proximal tubular cells.

bioRxiv · Dec 20, 2018Cell Biology