M. Martin

Vaginal lactobacilli produce anti-inflammatory beta-carboline compounds.

This study identifies beta-carboline compounds produced by vaginal lactobacilli that reduce inflammation by suppressing immune signaling pathways and demonstrate therapeutic potential in a mouse model.

SARS-CoV-2 Omicron XBB lineage spike structures, conformations, antigenicity, and receptor recognition

The paper determines cryo-EM structures of SARS-CoV-2 XBB lineage spike proteins, revealing structural changes that enhance immune evasion and receptor binding.

EZH2 deletion does not impact acinar cell regeneration but restricts progression to pancreatic cancer in mice

This study shows EZH2 deletion in adult acinar cells does not block regeneration but limits PDAC progression by altering the tumor microenvironment and differentiation.

Understanding the heterogeneity of alloreactive natural killer cell function inkidney transplantation

This study identifies NK cell subpopulations and their functional responses in kidney transplant patients, linking pre-transplant NK cell characteristics to long-term graft function.

The Wolbachia WalE1 effector alters Drosophila endocytosis

This study identifies WalE1, a Wolbachia effector that interacts with Past1 to alter endocytosis in Drosophila, increasing Wolbachia titer and affecting host cell processes.

Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively

This paper introduces RIPTACs, a new class of heterobifunctional small molecules that selectively kill cancer cells by inducing protein-protein interactions that disrupt essential cellular functions.

The Secreted Tyrosine Phosphatase PtpA promotes Staphylococcus aureus Intramacrophagic Survival Through Decrease of the SUMOylation Host Response

This study identifies PtpA as a secreted phosphatase that reduces host SUMOylation by lowering Ubc9 levels, enhancing S. aureus survival during long-term infection.

Insights into the structure and function of the human organic anion transporter 1 in lipid bilayer membranes

This study presents the first robust model of hOAT1 in outward-facing conformation using protein-threading and MD simulations, revealing structural and functional insights into its transport mechanism.

Biochemical characterization of Pectin Methylesterase Inhibitor 3 from Arabidopsis thaliana

This paper characterizes the biochemical activity of Arabidopsis thaliana PMEI3, showing its pH-dependent inhibition of PME activity and its effect on cell expansion.

Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike

This study determines cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike and compares them to BA.1, revealing structural changes and immune evasion mechanisms.

PRMT5 is a therapeutic target in choroidal neovascularization

This study identifies PRMT5 as a therapeutic target for neovascular age-related macular degeneration by showing its inhibition reduces NF-κB activity and angiogenic properties in ocular endothelial cells.

NKG2A and HLA-E define a novel alternative immune checkpoint axis in bladder cancer

This study identifies NKG2A and HLA-E as an alternative immune checkpoint axis in bladder cancer, showing NKG2A+ CD8 T cells can bypass HLA-ABC loss through TCR-independent cytotoxicity.

Evolution of bacterial persistence to antibiotics during a 50,000-generation experiment in an antibiotic-free environment

This study tracks the evolution of bacterial persistence over 50,000 generations in an antibiotic-free environment, finding that persistence levels can decrease or remain stable despite no environmental changes.

Structural diversity of the SARS-CoV-2 Omicron spike

The paper compares cryo-EM structures of SARS-CoV-2 Omicron and Delta spikes to analyze conformational changes affecting immune evasion and transmissibility.

Little hope for the polyploid endemic Pyrenean Larkspur (Delphinium montanum): evidences from population genomics and Ecological Niche Modelling

This study uses population genomics and ecological niche modeling to assess the conservation status of the endangered Pyrenean Larkspur, finding inbreeding, population structure, and habitat loss risks.

An Extended Motif in the SARS-CoV-2 Spike Modulates Binding and Release of Host Coatomer in Retrograde Trafficking

The paper identifies an extended COPI binding motif in the SARS-CoV-2 spike protein that modulates its interaction with COPI subunits and is critical for retrograde trafficking.

Evidence of long-term purging of mutation load in killer whale genomes

The paper examines mutation load in killer whale genomes, finding that high latitude populations have fewer non-synonymous mutations, suggesting purging of recessive deleterious mutations.

Cancer cell hyper-proliferation disrupts the topological invariance of epithelial monolayers

This study shows that cancer cell hyper-proliferation disrupts the topological order of epithelial monolayers, leading to random structures, while non-tumoral epithelia maintain ordered configurations.

Specific telomere protection ensured by FOXO3a upon genotoxic stress and during aging

The paper shows FOXO3a protects telomeres during aging and genotoxic stress, linking it to longevity pathways.

Turning plants from passive to active material: FERONIA and microtubules independently contribute to mechanical feedback

The paper investigates the role of FERONIA and microtubules in plant cell mechanical feedback, showing they function as independent pathways to resist stress.

A Mycobacterium tuberculosis effector targets mitochondrion, controls energy metabolism and limits cytochrome c exit.

This study identifies Rv1813c, a Mycobacterium tuberculosis effector that targets mitochondria, enhances ATP production, and delays cytochrome c release, thereby modulating host metabolism and apoptosis.

Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells.

This study shows that KIF21B limits microtubule growth to enable rapid centrosome polarization in T cells by inducing microtubule pausing and catastrophe.

Privatization of biofilm matrix in structurally heterogeneous biofilms

The paper investigates structural heterogeneity in biofilms, showing that matrix gene expression varies and that producer cells maintain partial privatization of the matrix, enhancing biofilm robustness.

Concerted action of kinesins KIF5B and KIF13B promotes efficient secretory vesicle transport to microtubule plus ends

The paper shows that KIF5B and KIF13B work together to transport secretory vesicles to microtubule plus ends, with KIF5B playing a dominant role and KIF13B assisting in reaching newly polymerized ends.

Loss of Activating Transcription Factor 3 prevents KRAS-mediated pancreatic cancer

This study shows that loss of ATF3 reduces pancreatic cancer progression by limiting acinar-to-ductal metaplasia and enhancing regeneration, but KRASG12D can bypass ATF3's requirement in some contexts.

Driving factors of conifer regeneration dynamics in eastern Canadian boreal old-growth forests

This study identifies the main drivers of conifer regeneration dynamics in eastern Canadian boreal old-growth forests, focusing on black spruce and balsam fir.

Cheaters shape the evolution of phenotypic heterogeneity in Bacillus subtilis biofilms

This study shows that EPS-deficient cheaters in Bacillus subtilis biofilms increase phenotypic heterogeneity, leading to adaptive strategies that enhance EPS production in the presence of cheaters.

Microbiota Assembly, Structure, and Dynamics Among Tsimane Horticulturalists of the Bolivian Amazon

This study examines microbiota assembly in Tsimane infants and adults, finding that neutral processes dominate infant colonization, but are reduced in villages with more market access.

Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease

This study identifies aberrant DNA methylation in mesenchymal stromal cells from myeloma patients and shows that targeting DNMTs and G9a with CM-272 reverses bone loss and reduces tumor burden.

Xyloglucan homeostasis and microtubule dynamics synergistically maintain meristem geometry and robustness of phyllotaxis in Arabidopsis

This study shows that xyloglucan homeostasis and microtubule dynamics work together to maintain meristem geometry and phyllotaxis in Arabidopsis.